Hello everyone and good day. In our last section, we talked about glia
cells, what they were, and how they work. In this section, we begin talking
about the neuron. To do that, we first must talk about what we call the
neuronal classification systems.As we go to slide
two, we can see that the neuron is classified in a variety of different
ways. The first way to classify it is by the number of processes, second by
function, third by speed, and fourth by nucleus to cytoplasmic ratio.
There are also other ways that the neurons are
classified. Some are classified by the type of neuro-transmitter that’s
excreted, and others are classified by the effects the neuro-transmitter has
on the postsynaptic element. So, let’s talk about each of these and kind
of give you an idea about what they are. We will talk about the number of
processes first.
Neurons are classified for the number of processes three
different ways by the number of processes that come off of the Soma. The
first type of neuron is what we call a unipolar neuron. A unipolar neuron
is shown in slide four. It has one stock that comes off the Soma and splits
into two branches. As you can see here, there are two different shapes that
you normally see. The top unipolar neuron one has one process come off
(which is an axon) and then it’s going to branch and do assorted other
things. The second one is shaped like a T except it is a little, short T,
rather than a long T. This is the shape of a T cell that you find in the
spinal cord the first unipolar neuron is oftentimes found in newborns in the
brain).
T cells are extremely important in sending information and
we talk a little bit about that when we talk about the spinal column. So,
again, the first type of way that you classify neurons by processes is with
a unipolar neuron having one structure coming off the Soma. The second way
that we look at neuron with the number of processes are what are called
bipolar neurons While unipolar (uni meaning one structure came off the
Soma); in a bipolar neuron you have one axon and one dendrite that comes off
the Soma. You can see this in slide five. Basically, where we find bipolar
neurons are in the retina of the eye.
The next type of neuron that we see is what we call the
multipolar neuron. In a multipolar neuron what you have are multiple
dendrites and one axon coming off a particular Soma. So, what you’re having
are multiple structures rather than one or two. Again each of these neuron
types is going to have their own specific role. But, as you notice in each
of these three examples, there’s only one axon (that may split) but there
may be multiple dendrites.
So, the first way that we’ve classified neurons was by the
number of processes. The second way that we classify neurons is by function,
and this is shown in slide seven. By function what we have are three
different types. We first have afferent or sensory neurons. These
basically are going to get information from receptors and send them to the
central nervous system (usually the spinal cord). Next, we have
internuncial neurons (or what we also call interneurons) that we talked a
little bit about previously in the spinal cord. Basically they are going to
connect afferent neurons and the next type of neuron, which are called
efferent neurons. Efferent neurons are motor neurons. Basically, they get
information from the central nervous system and send it to muscle cells in
the peripheral nervous system. So again, (as we see on the next slide),
what we have is an afferent neuron coming through, branching with some
information going to the brain and some going to an internuncial neuron.
Internuncial neurons then connect to an efferent neuron which will go back
out to the peripheral nervous system.
The third way that we classify neurons is by speed. This
is called the Glasser system. The Glasser system basically has three
different types of neurons; type A, type B and type C. Type A are the
fastest neurons. They go about 120 meters a second, or about 270 miles an
hour. Now, you may think that’s relatively slow in relation to systems, but
since your body is only about six feet, that’s really pretty fast. The big
thing about type A neurons is that they’re heavily milanated and they’re
relatively large. Usually you see these neurons when concerned with pain
types of systems. So, you’re going to see a lot of these are coming out of
the spinal cord and going up and down to the brain. So they are heavily
myelinated neurons, relatively large, and that send information very, very
rapidly.
The second type are what we call type B neurons. Type Bs
are much smaller than type A neurons. They are also milanated but they’re
slower. Their speed is only about 3 to 15 meters per second. You might see
these in pathways of the brain, whereas with Type A’s, you might see them in
the spinal cord.
Type C neurons are very slow. They’re only going to go to
.6 to 2 meters per second. So, they’re not going very fast. Again, they’re
relatively small. As we can see, but the big thing about type C neurons is
that they’re nonmelinated. Basically, they’re going to be concerned with
dull or throbbing pain that’s going to last for a long period of time. The
classic example of this might be a toothache.
So, how do these neurons work together? Well, let’s say
that you cut your hand. What you’re going to feel? The initial cutting
begins and the initial pain system is going to be from a type A neuron and
that’s going to say, “Get my hand away from this sharp object.” Then you’re
going to have type Cs being activated, which are going to be slower. Then
you’re going to have a dull or a throbbing pain.
The next way that we classify neurons is what we call
nucleus to cytoplasmic ratio. Basically, this is the ratio that compares
nucleus size to the surrounding cytoplasm. There are a couple of different
cells that you see here. In one type of cell which we call Stelate cells,
you see large nuclei with relatively little cytoplasm, whereas in pyramidal
cells you see a small nucleus with large amounts of cytoplasm plasma. These
are going to be related to the kind of cells that they work with. Usually
Pyramidal cells are concerned with motor movement and Stelate cells tend to
be more sensory.
Ok, so we’ve talked now about the four major schemes in
relation to classifying neurons. There’s also a couple of other ways. So,
let’s talk about them for a second. Basically, as we saw earlier, the type
of neuro-transmitters secreted by the neuron is one way that we classify
neurons. So, we call them, for example, dopaminergic neurons or a
gabanergic neurons or something to that extent. Or, we also talk about
their effect. So, if they’re excitatory neurons, we will call them
excitatory, and inhibitory if they inhibit. One type causes excitatory
signals in the next neuron fires while the other shuts that neuron down.
These classification systems aren’t used as much, but they are still used
out there and you need to be aware of them.
Ok, we’ve talked now about some types of neuro
classification schemes. In the next section we’re going to talk about the
different neuron structures, how they work, and what they do. So until
then, we hope you’re enjoying the lecture and have yourself a great day.
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